Magnolol Enhances the Therapeutic Effects of TRAIL through DR5 Upregulation and Downregulation of c-FLIP and Mcl-1 Proteins in Cancer Cells.

Woo, Seon Min; Min, Kyoung-Jin; Kwon, Taeg Kyu

Woo, Seon Min; Min, Kyoung-Jin; Kwon, Taeg Kyu.

Affiliation

Woo SM; Department of Immunology, School of Medicine, Keimyung University, 1095 Dalgubeoldaero, Dalseo-Gu, Daegu 42601, Korea.
Min KJ; Department of Immunology, School of Medicine, Keimyung University, 1095 Dalgubeoldaero, Dalseo-Gu, Daegu 42601, Korea.
Kwon TK; New Drug Development Center, Deagu-Gyeongbuk Medical Innovation Foundation, 80 Chembok-ro, Dong-gu, Daegu 41061, Korea.

Molecules ; 25(19)2020 Oct 08.

Article in En | MEDLINE | ID: mdl-33050112

Subject(s)

Biphenyl Compounds/pharmacology; CASP8 and FADD-Like Apoptosis Regulating Protein/genetics; Down-Regulation/drug effects; Lignans/pharmacology; Myeloid Cell Leukemia Sequence 1 Protein/genetics; Neoplasms/drug therapy; Receptors, TNF-Related Apoptosis-Inducing Ligand/genetics; TNF-Related Apoptosis-Inducing Ligand/genetics; Up-Regulation/drug effects; A549 Cells; Apoptosis/drug effects; Apoptosis/genetics; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Proliferation/genetics; Down-Regulation/genetics; HeLa Cells; Humans; Neoplasms/genetics; Proteasome Endopeptidase Complex/genetics; Up-Regulation/genetics

Key words

DR5; Mcl-1; TRAIL; c-FLIP; magnolol

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Full text: 1 Database: MEDLINE Main subject: Biphenyl Compounds / Down-Regulation / Up-Regulation / Lignans / TNF-Related Apoptosis-Inducing Ligand / CASP8 and FADD-Like Apoptosis Regulating Protein / Receptors, TNF-Related Apoptosis-Inducing Ligand / Myeloid Cell Leukemia Sequence 1 Protein / Neoplasms Limits: Humans Language: En Year: 2020 Type: Article

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