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Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon.
Finney, Lydia J; Glanville, Nicholas; Farne, Hugo; Aniscenko, Julia; Fenwick, Peter; Kemp, Samuel V; Trujillo-Torralbo, Maria-Belen; Loo, Su Ling; Calderazzo, Maria Adelaide; Wedzicha, Jadwiga A; Mallia, Patrick; Bartlett, Nathan W; Johnston, Sebastian L; Singanayagam, Aran.
Affiliation
  • Finney LJ; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Glanville N; Prokarium, London BioScience Innovation Centre, London, United Kingdom.
  • Farne H; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Aniscenko J; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Fenwick P; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Kemp SV; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Royal Brompton and Harefield NHS Trust, London, United Kingdom.
  • Trujillo-Torralbo MB; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Loo SL; Faculty of Health and Medicine and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle, Newcastle, United Kingdom.
  • Calderazzo MA; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Wedzicha JA; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Mallia P; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Bartlett NW; Faculty of Health and Medicine and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle, Newcastle, United Kingdom.
  • Johnston SL; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Singanayagam A; National Heart and Lung Institute, Imperial College London, London, United Kingdom. Electronic address: a.singanayagam@imperial.ac.uk.
J Allergy Clin Immunol ; 147(2): 510-519.e5, 2021 Feb.
Article in En | MEDLINE | ID: mdl-33068560
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Full text: 1 Database: MEDLINE Main subject: Interferon Type I / Adrenal Cortex Hormones / Pulmonary Disease, Chronic Obstructive / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 / COVID-19 Limits: Aged / Animals / Female / Humans / Male / Middle aged Language: En Year: 2021 Type: Article
Fulltext
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PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Interferon Type I / Adrenal Cortex Hormones / Pulmonary Disease, Chronic Obstructive / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 / COVID-19 Limits: Aged / Animals / Female / Humans / Male / Middle aged Language: En Year: 2021 Type: Article