Characterisation of gas exchange in COPD with dissolved-phase hyperpolarised xenon-129 MRI.
Thorax
; 76(2): 178-181, 2021 02.
Article
in En
| MEDLINE
| ID: mdl-33139449
ABSTRACT
To investigate whether hyperpolarised xenon-129 MRI (HXeMRI) enables regional and physiological resolution of diffusing capacity limitations in chronic obstructive pulmonary disease (COPD), we evaluated 34 COPD subjects and 11 healthy volunteers. We report significant correlations between airflow abnormality quantified by HXeMRI and per cent predicted forced expiratory volume in 1 s; HXeMRI gas transfer capacity to red blood cells and carbon monoxide diffusion capacity (%DLCO); and HXeMRI gas transfer capacity to interstitium and per cent emphysema quantified by multidetector chest CT. We further demonstrate the capability of HXeMRI to distinguish varying pathology underlying COPD in subjects with low %DLCO and minimal emphysema.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Magnetic Resonance Imaging
/
Pulmonary Gas Exchange
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Pulmonary Disease, Chronic Obstructive
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Year:
2021
Type:
Article