Inhibitor of Hyaluronic Acid Synthesis 4-Methylumbelliferone as an Anti-Inflammatory Modulator of LPS-Mediated Astrocyte Responses.

Chistyakov, Dmitry V; Nikolskaya, Arina I; Goriainov, Sergei V; Astakhova, Alina A; Sergeeva, Marina G

Chistyakov, Dmitry V; Nikolskaya, Arina I; Goriainov, Sergei V; Astakhova, Alina A; Sergeeva, Marina G.

Affiliation

Chistyakov DV; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.
Nikolskaya AI; SREC PFUR, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia.
Goriainov SV; Faculty of Bioengineering and Bioinformatics, Moscow Lomonosov State University, 119234 Moscow, Russia.
Astakhova AA; SREC PFUR, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia.
Sergeeva MG; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.

Int J Mol Sci ; 21(21)2020 Nov 02.

Article in En | MEDLINE | ID: mdl-33147798

Subject(s)

Anti-Inflammatory Agents/pharmacology; Astrocytes/drug effects; Hyaluronic Acid/antagonists & inhibitors; Hymecromone/pharmacology; Animals; Animals, Newborn; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases/metabolism; Female; Inflammation; Interleukin-10/metabolism; Interleukin-1beta/metabolism; Interleukin-6/metabolism; Lipopolysaccharides; MAP Kinase Signaling System; Male; NF-kappa B/metabolism; Oxylipins/metabolism; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Tandem Mass Spectrometry; Tumor Necrosis Factor-alpha/metabolism

Key words

4-methylumbelliferone (4-MU); astrocytes; cyclooxygenase (COX); hyaluronic acid; interleukin 10 (IL-10); interleukin 6 (IL-6); neuroinflammation; oxylipins; toll-like receptors (TLRs)

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Full text: 1 Database: MEDLINE Main subject: Hymecromone / Astrocytes / Hyaluronic Acid / Anti-Inflammatory Agents Limits: Animals Language: En Year: 2020 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Hymecromone / Astrocytes / Hyaluronic Acid / Anti-Inflammatory Agents Limits: Animals Language: En Year: 2020 Type: Article