Appended Aromatic Moieties in Flexible Bis-3-chloropiperidines Confer Tropism against Pancreatic Cancer Cells.

Carraro, Caterina; Helbing, Tim; Francke, Alexander; Zuravka, Ivonne; Sosic, Alice; De Franco, Michele; Gandin, Valentina; Gatto, Barbara; Göttlich, D Richard

Carraro, Caterina; Helbing, Tim; Francke, Alexander; Zuravka, Ivonne; Sosic, Alice; De Franco, Michele; Gandin, Valentina; Gatto, Barbara; Göttlich, D Richard.

Affiliation

Carraro C; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Francesco Marzolo 5, 35131, Padova, Italy.
Helbing T; Institute of Organic Chemistry, Justus Liebig University Giessen, Heinrich-Buff-Ring 17, 35392, Giessen, Germany.
Francke A; Institute of Organic Chemistry, Justus Liebig University Giessen, Heinrich-Buff-Ring 17, 35392, Giessen, Germany.
Zuravka I; Institute of Organic Chemistry, Justus Liebig University Giessen, Heinrich-Buff-Ring 17, 35392, Giessen, Germany.
Sosic A; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Francesco Marzolo 5, 35131, Padova, Italy.
De Franco M; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Francesco Marzolo 5, 35131, Padova, Italy.
Gandin V; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Francesco Marzolo 5, 35131, Padova, Italy.
Gatto B; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Francesco Marzolo 5, 35131, Padova, Italy.
Göttlich DR; Institute of Organic Chemistry, Justus Liebig University Giessen, Heinrich-Buff-Ring 17, 35392, Giessen, Germany.

ChemMedChem ; 16(5): 860-868, 2021 03 03.

Article in En | MEDLINE | ID: mdl-33200541

Subject(s)

Antineoplastic Agents/pharmacology; Pancreatic Neoplasms/drug therapy; Piperidines/pharmacology; Antineoplastic Agents/chemistry; Cell Proliferation/drug effects; Cell Survival/drug effects; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Pancreatic Neoplasms/metabolism; Pancreatic Neoplasms/pathology; Piperidines/chemistry; Structure-Activity Relationship; Tumor Cells, Cultured

Key words

DNA alkylation; anticancer agents; nitrogen mustards; pancreatic cancer; spheroids

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Full text: 1 Database: MEDLINE Main subject: Pancreatic Neoplasms / Piperidines / Antineoplastic Agents Limits: Humans Language: En Year: 2021 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Pancreatic Neoplasms / Piperidines / Antineoplastic Agents Limits: Humans Language: En Year: 2021 Type: Article