Demethoxycurcumin analogue DMC-BH exhibits potent anticancer effects on orthotopic glioblastomas.

Shi, Lei; Sun, Guan; Zhang, Yong

Shi, Lei; Sun, Guan; Zhang, Yong.

Affiliation

Shi L; Department of Neurosurgery, Affiliated Kunshan Hospital of Jiangsu University, Suzhou 215300, P.R. China.
Sun G; Department of Neurosurgery, The Fourth Affiliated Hospital of Nantong University, Yancheng City First People's Hospital, Yancheng 224000, P. R. China.
Zhang Y; Department of Neurosurgery, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210029, P.R. China.

Aging (Albany NY) ; 12(23): 23795-23807, 2020 11 18.

Article in En | MEDLINE | ID: mdl-33221748

Subject(s)

Antineoplastic Agents, Phytogenic/pharmacology; Brain Neoplasms/drug therapy; Diarylheptanoids/pharmacology; Glioblastoma/drug therapy; Animals; Antineoplastic Agents, Phytogenic/pharmacokinetics; Antineoplastic Agents, Phytogenic/therapeutic use; Apoptosis/drug effects; Brain Neoplasms/metabolism; Brain Neoplasms/pathology; Cell Line, Tumor; Cell Proliferation/drug effects; Diarylheptanoids/pharmacokinetics; Diarylheptanoids/therapeutic use; Female; Glioblastoma/metabolism; Glioblastoma/pathology; Humans; Ki-67 Antigen/metabolism; Male; Mice, Inbred ICR; Mice, Nude; Mice, SCID; Phosphorylation; Proto-Oncogene Proteins c-akt/metabolism; Rats, Sprague-Dawley; Signal Transduction; TOR Serine-Threonine Kinases/metabolism; Tumor Burden/drug effects; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

Key words

DMC-BH; apoptosis; demethoxycurcumin; glioblastoma; proliferation

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Full text: 1 Database: MEDLINE Main subject: Brain Neoplasms / Glioblastoma / Diarylheptanoids / Antineoplastic Agents, Phytogenic Limits: Animals / Female / Humans / Male Language: En Year: 2020 Type: Article

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