Humanized C3 Mouse: A Novel Accelerated Model of C3 Glomerulopathy.

Devalaraja-Narashimha, Kishor; Meagher, Karoline; Luo, Yifan; Huang, Cong; Kaplan, Theodore; Muthuswamy, Anantharaman; Halasz, Gabor; Casanova, Sarah; O'Brien, John; Peyser Boiarsky, Rebecca; McWhirter, John; Gartner, Hans; Bai, Yu; MacDonnell, Scott; Liu, Chien; Hu, Ying; Latuszek, Adrianna; Wei, Yi; Prasad, Srinivasa; Huang, Tammy; Yancopoulos, George; Murphy, Andrew; Olson, William; Zambrowicz, Brian; Macdonald, Lynn; Morton, Lori G

Devalaraja-Narashimha, Kishor; Meagher, Karoline; Luo, Yifan; Huang, Cong; Kaplan, Theodore; Muthuswamy, Anantharaman; Halasz, Gabor; Casanova, Sarah; O'Brien, John; Peyser Boiarsky, Rebecca; McWhirter, John; Gartner, Hans; Bai, Yu; MacDonnell, Scott; Liu, Chien; Hu, Ying; Latuszek, Adrianna; Wei, Yi; Prasad, Srinivasa; Huang, Tammy; Yancopoulos, George; Murphy, Andrew; Olson, William; Zambrowicz, Brian; Macdonald, Lynn; Morton, Lori G.

Affiliation

Devalaraja-Narashimha K; Regeneron Pharmaceuticals, Tarrytown, New York.

J Am Soc Nephrol ; 32(1): 99-114, 2021 01.

Article in En | MEDLINE | ID: mdl-33288630

Subject(s)

Complement C3/genetics; Disease Models, Animal; Glomerulonephritis, Membranoproliferative/genetics; Kidney Diseases/genetics; Animals; Complement C3/metabolism; Complement Pathway, Alternative/genetics; Exons; Gene Expression Regulation; Glomerulonephritis, Membranoproliferative/metabolism; Humans; Kidney Diseases/metabolism; Liver/metabolism; Male; Mice; Mice, Knockout; Microscopy, Fluorescence; Phenotype; Polymorphism, Single Nucleotide; Renal Insufficiency/genetics; Renal Insufficiency/metabolism

Key words

C2 KO; C3 glomerulopathy; C3b; C5; CFH mAbs; accelerated kidney disease; humanized C3 mice; liver phenotype; mouse model

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Full text: 1 Database: MEDLINE Main subject: Complement C3 / Glomerulonephritis, Membranoproliferative / Disease Models, Animal / Kidney Diseases Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Year: 2021 Type: Article

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