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A cell competition-based small molecule screen identifies a novel compound that induces dual c-Myc depletion and p53 activation.
Tadele, Dagim Shiferaw; Robertson, Joseph; Crispin, Richard; Herrera, Maria C; Chlubnová, Markéta; Piechaczyk, Laure; Ayuda-Durán, Pilar; Singh, Sachin Kumar; Gedde-Dahl, Tobias; Fløisand, Yngvar; Skavland, Jørn; Wesche, Jørgen; Gjertsen, Bjørn-Tore; Enserink, Jorrit M.
Affiliation
  • Tadele DS; Department of Molecular Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway.
  • Robertson J; Department of Molecular Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway.
  • Crispin R; Department of Molecular Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway.
  • Herrera MC; Section for Biochemistry and Molecular Biology, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.
  • Chlubnová M; Department of Molecular Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway.
  • Piechaczyk L; Department of Molecular Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway.
  • Ayuda-Durán P; Department of Molecular Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway.
  • Singh SK; Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway.
  • Gedde-Dahl T; Department of Hematology, Oslo University Hospital, Oslo, Norway.
  • Fløisand Y; Department of Hematology, Oslo University Hospital, Oslo, Norway.
  • Skavland J; Precision Oncology Research Group, Department of Clinical Science, University of Bergen, Bergen, Norway.
  • Wesche J; Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway.
  • Gjertsen BT; Precision Oncology Research Group, Department of Clinical Science, University of Bergen, Bergen, Norway.
  • Enserink JM; Department of Molecular Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway. Electronic address: jorrit.enserink@ibv.uio.no.
J Biol Chem ; 296: 100179, 2021.
Article in En | MEDLINE | ID: mdl-33303632
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Full text: 1 Database: MEDLINE Main subject: Drug Screening Assays, Antitumor / Tumor Suppressor Protein p53 / Proto-Oncogene Proteins c-myc / Small Molecule Libraries / Cell Competition / Antineoplastic Agents Limits: Humans Language: En Year: 2021 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Drug Screening Assays, Antitumor / Tumor Suppressor Protein p53 / Proto-Oncogene Proteins c-myc / Small Molecule Libraries / Cell Competition / Antineoplastic Agents Limits: Humans Language: En Year: 2021 Type: Article