SCRT1 is a novel beta cell transcription factor with insulin regulatory properties.

Chriett, S; Lindqvist, A; Shcherbina, L; Edlund, A; Abels, M; Asplund, O; Martínez López, J A; Ottosson-Laakso, E; Hatem, G; Prasad, R B; Groop, L; Eliasson, L; Hansson, O; Wierup, N

Chriett, S; Lindqvist, A; Shcherbina, L; Edlund, A; Abels, M; Asplund, O; Martínez López, J A; Ottosson-Laakso, E; Hatem, G; Prasad, R B; Groop, L; Eliasson, L; Hansson, O; Wierup, N.

Affiliation

Chriett S; Lund University Diabetes Centre, Malmö, Sweden.
Lindqvist A; Lund University Diabetes Centre, Malmö, Sweden.
Shcherbina L; Lund University Diabetes Centre, Malmö, Sweden.
Edlund A; Lund University Diabetes Centre, Malmö, Sweden.
Abels M; Lund University Diabetes Centre, Malmö, Sweden.
Asplund O; Lund University Diabetes Centre, Malmö, Sweden.
Martínez López JA; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Ottosson-Laakso E; Lund University Diabetes Centre, Malmö, Sweden.
Hatem G; Lund University Diabetes Centre, Malmö, Sweden.
Prasad RB; Lund University Diabetes Centre, Malmö, Sweden.
Groop L; Lund University Diabetes Centre, Malmö, Sweden; Finnish Institute of Molecular Medicine, Helsinki, Finland.
Eliasson L; Lund University Diabetes Centre, Malmö, Sweden.
Hansson O; Lund University Diabetes Centre, Malmö, Sweden; Finnish Institute of Molecular Medicine, Helsinki, Finland.
Wierup N; Lund University Diabetes Centre, Malmö, Sweden. Electronic address: nils.wierup@med.lu.se.

Mol Cell Endocrinol ; 521: 111107, 2021 02 05.

Article in En | MEDLINE | ID: mdl-33309639

Subject(s)

Diabetes Mellitus, Type 2/metabolism; Gene Expression Regulation/genetics; Glucose/metabolism; Insulin-Secreting Cells/metabolism; Insulin/metabolism; Transcription Factors/metabolism; Animals; Apoptosis/drug effects; Apoptosis/genetics; Cell Line; Cell Nucleus/genetics; Cell Nucleus/metabolism; Chromatin Immunoprecipitation; Cytoplasm/genetics; Cytoplasm/metabolism; Disease Models, Animal; Gene Expression Regulation/drug effects; Gene Silencing; Humans; Immunohistochemistry; Insulin/genetics; Insulin Secretion/drug effects; Insulin-Secreting Cells/drug effects; Male; Mice; Mice, Inbred C57BL; RNA, Small Interfering; RNA-Seq; Real-Time Polymerase Chain Reaction; Single-Cell Analysis; Transcription Factors/genetics

Key words

Beta cell; INS-1 832/13; Insulin secretion; SCRT1; Type 2 diabetes

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Full text: 1 Database: MEDLINE Main subject: Transcription Factors / Gene Expression Regulation / Diabetes Mellitus, Type 2 / Insulin-Secreting Cells / Glucose / Insulin Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Year: 2021 Type: Article

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