Your browser doesn't support javascript.
loading
Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands.
Ferri, Elena; Le Thomas, Adrien; Wallweber, Heidi Ackerly; Day, Eric S; Walters, Benjamin T; Kaufman, Susan E; Braun, Marie-Gabrielle; Clark, Kevin R; Beresini, Maureen H; Mortara, Kyle; Chen, Yung-Chia A; Canter, Breanna; Phung, Wilson; Liu, Peter S; Lammens, Alfred; Ashkenazi, Avi; Rudolph, Joachim; Wang, Weiru.
Affiliation
  • Ferri E; Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Le Thomas A; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Wallweber HA; Cancer Immunology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Day ES; Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Walters BT; Pharmaceutical Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Kaufman SE; Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Braun MG; Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Clark KR; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Beresini MH; Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Mortara K; Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Chen YA; BioMolecular Resources, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Canter B; Cancer Immunology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Phung W; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Liu PS; Microchemistry, Proteomics & Lipidomics, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Lammens A; Microchemistry, Proteomics & Lipidomics, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Ashkenazi A; Proteros Biostructures GmbH, Bunsenstr. 7a, D - 82152, Martinsried, Germany.
  • Rudolph J; Cancer Immunology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
  • Wang W; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA. rudolph.joachim@gene.com.
Nat Commun ; 11(1): 6387, 2020 12 14.
Article in En | MEDLINE | ID: mdl-33318494
Subject(s)
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Ribonucleases / Adenosine Triphosphate / Protein Serine-Threonine Kinases / Endoribonucleases Type of study: Prognostic_studies Limits: Humans Language: En Year: 2020 Type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Ribonucleases / Adenosine Triphosphate / Protein Serine-Threonine Kinases / Endoribonucleases Type of study: Prognostic_studies Limits: Humans Language: En Year: 2020 Type: Article