The end protection problem-an unexpected twist in the tail.
Genes Dev
; 35(1-2): 1-21, 2021 01 01.
Article
in En
| MEDLINE
| ID: mdl-33361389
ABSTRACT
In this perspective, we introduce shelterin and the mechanisms of ATM activation and NHEJ at telomeres, before discussing the following questions How are t-loops proposed to protect chromosome ends and what is the evidence for this model? Can other models explain how TRF2 mediates end protection? Could t-loops be pathological structures? How is end protection achieved in pluripotent cells? What do the insights into telomere end protection in pluripotent cells mean for the t-loop model of end protection? Why might different cell states have evolved different mechanisms of end protection? Finally, we offer support for an updated t-loop model of end protection, suggesting that the data is supportive of a critical role for t-loops in protecting chromosome ends from NHEJ and ATM activation, but that other mechanisms are involved. Finally, we propose that t-loops are likely dynamic, rather than static, structures.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Telomere
/
DNA Breaks, Double-Stranded
/
DNA End-Joining Repair
Limits:
Animals
/
Humans
Language:
En
Year:
2021
Type:
Article