Conformational rearrangement during activation of a metabotropic glutamate receptor.

Liauw, Brandon Wey-Hung; Afsari, Hamid Samareh; Vafabakhsh, Reza

Liauw, Brandon Wey-Hung; Afsari, Hamid Samareh; Vafabakhsh, Reza.

Affiliation

Liauw BW; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Afsari HS; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Vafabakhsh R; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA. reza.vafabakhsh@northwestern.edu.

Nat Chem Biol ; 17(3): 291-297, 2021 03.

Article in En | MEDLINE | ID: mdl-33398167

Subject(s)

Glutamic Acid/chemistry; Receptors, Metabotropic Glutamate/chemistry; Allosteric Regulation; Amino Acids/pharmacology; Binding Sites; Biosensing Techniques; Bridged Bicyclo Compounds, Heterocyclic/pharmacology; Cyclopropanes/pharmacology; Fluorescence Resonance Energy Transfer; Gene Expression; Genetic Vectors/chemistry; Genetic Vectors/metabolism; Glutamic Acid/pharmacology; Glycine/analogs & derivatives; Glycine/pharmacology; HEK293 Cells; Humans; Ligands; Models, Molecular; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Multimerization/drug effects; Receptors, Metabotropic Glutamate/agonists; Receptors, Metabotropic Glutamate/genetics; Receptors, Metabotropic Glutamate/metabolism; Single Molecule Imaging

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Full text: 1 Database: MEDLINE Main subject: Receptors, Metabotropic Glutamate / Glutamic Acid Limits: Humans Language: En Year: 2021 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Receptors, Metabotropic Glutamate / Glutamic Acid Limits: Humans Language: En Year: 2021 Type: Article