A Potent and Selective Dual Inhibitor of AXL and MERTK Possesses Both Immunomodulatory and Tumor-Targeted Activity. | Front Oncol;10: 598477, 2020. | MEDLINE

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A Potent and Selective Dual Inhibitor of AXL and MERTK Possesses Both Immunomodulatory and Tumor-Targeted Activity.

Rios-Doria, Jonathan; Favata, Margaret; Lasky, Kerri; Feldman, Patricia; Lo, Yvonne; Yang, Gengjie; Stevens, Christina; Wen, Xiaoming; Sehra, Sarita; Katiyar, Kamna; Liu, Ke; Wynn, Richard; Harris, Jennifer J; Ye, Min; Spitz, Susan; Wang, Xiaozhao; He, Chunhong; Li, Yun-Long; Yao, Wenqing; Covington, Maryanne; Scherle, Peggy; Koblish, Holly.

Affiliation

Rios-Doria J; Incyte Research Institute, Wilmington, DE, United States.
Favata M; Incyte Research Institute, Wilmington, DE, United States.
Lasky K; Incyte Research Institute, Wilmington, DE, United States.
Feldman P; Incyte Research Institute, Wilmington, DE, United States.
Lo Y; Incyte Research Institute, Wilmington, DE, United States.
Yang G; Incyte Research Institute, Wilmington, DE, United States.
Stevens C; Incyte Research Institute, Wilmington, DE, United States.
Wen X; Incyte Research Institute, Wilmington, DE, United States.
Sehra S; Incyte Research Institute, Wilmington, DE, United States.
Katiyar K; Incyte Research Institute, Wilmington, DE, United States.
Liu K; Incyte Research Institute, Wilmington, DE, United States.
Wynn R; Incyte Research Institute, Wilmington, DE, United States.
Harris JJ; Incyte Research Institute, Wilmington, DE, United States.
Ye M; Incyte Research Institute, Wilmington, DE, United States.
Spitz S; Incyte Research Institute, Wilmington, DE, United States.
Wang X; Incyte Research Institute, Wilmington, DE, United States.
He C; Incyte Research Institute, Wilmington, DE, United States.
Li YL; Incyte Research Institute, Wilmington, DE, United States.
Yao W; Incyte Research Institute, Wilmington, DE, United States.
Covington M; Incyte Research Institute, Wilmington, DE, United States.
Scherle P; Incyte Research Institute, Wilmington, DE, United States.
Koblish H; Incyte Research Institute, Wilmington, DE, United States.

Front Oncol ; 10: 598477, 2020.

Article in En | MEDLINE | ID: mdl-33425754

Key words

AXL; MERTK; PD-L1; antitumor activity; dual inhibitor; immunotherapy; small molecule

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Full text: 1 Database: MEDLINE Language: En Year: 2020 Type: Article

Search on Google

Full text: 1 Database: MEDLINE Language: En Year: 2020 Type: Article