Structural insights into DNA double-strand break signaling.

Panigrahi, Rashmi; Glover, J N Mark

Panigrahi, Rashmi; Glover, J N Mark.

Affiliation

Panigrahi R; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Glover JNM; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.

Biochem J ; 478(1): 135-156, 2021 01 15.

Article in En | MEDLINE | ID: mdl-33439989

Subject(s)

DNA Breaks, Double-Stranded; DNA Repair/genetics; Signal Transduction/genetics; Acid Anhydride Hydrolases/chemistry; Acid Anhydride Hydrolases/metabolism; Animals; Ataxia Telangiectasia Mutated Proteins/chemistry; Ataxia Telangiectasia Mutated Proteins/metabolism; Cell Cycle Proteins/chemistry; Cell Cycle Proteins/metabolism; DNA Damage/genetics; DNA-Binding Proteins/chemistry; DNA-Binding Proteins/metabolism; Humans; MRE11 Homologue Protein/chemistry; MRE11 Homologue Protein/metabolism; Nuclear Proteins/chemistry; Nuclear Proteins/metabolism; Protein Processing, Post-Translational/genetics; Tumor Suppressor Proteins/chemistry; Tumor Suppressor Proteins/metabolism; Tumor Suppressor p53-Binding Protein 1/chemistry; Tumor Suppressor p53-Binding Protein 1/metabolism; Ubiquitin-Protein Ligases/chemistry; Ubiquitin-Protein Ligases/metabolism

Key words

DNA damage signaling; mediators; phosphorylation; sensors; ubiquitylation

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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / DNA Repair / DNA Breaks, Double-Stranded Limits: Animals / Humans Language: En Year: 2021 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / DNA Repair / DNA Breaks, Double-Stranded Limits: Animals / Humans Language: En Year: 2021 Type: Article