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Haplotype structure defines effects of common DPYD variants c.85T > C (rs1801265) and c.496A > G (rs2297595) on dihydropyrimidine dehydrogenase activity: Implication for 5-fluorouracil toxicity.
Hamzic, Seid; Schärer, Dominic; Offer, Steven M; Meulendijks, Didier; Nakas, Christos; Diasio, Robert B; Fontana, Stefano; Wehrli, Marc; Schürch, Stefan; Amstutz, Ursula; Largiadèr, Carlo R.
Affiliation
  • Hamzic S; Institute of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern, INO-F, Bern, Switzerland.
  • Schärer D; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
  • Offer SM; Institute of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern, INO-F, Bern, Switzerland.
  • Meulendijks D; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
  • Nakas C; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
  • Diasio RB; Department of Clinical Pharmacology, Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Fontana S; Institute of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern, INO-F, Bern, Switzerland.
  • Wehrli M; Laboratory of Biometry, University of Thessaly, Volos, Greece.
  • Schürch S; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
  • Amstutz U; Regional Blood Transfusion Service of the Swiss RedCross, Bern, Switzerland.
  • Largiadèr CR; Department of Medical Oncology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
Br J Clin Pharmacol ; 87(8): 3234-3243, 2021 08.
Article in En | MEDLINE | ID: mdl-33491253
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Full text: 1 Database: MEDLINE Main subject: Dihydrouracil Dehydrogenase (NADP) / Drug-Related Side Effects and Adverse Reactions Limits: Humans Language: En Year: 2021 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Dihydrouracil Dehydrogenase (NADP) / Drug-Related Side Effects and Adverse Reactions Limits: Humans Language: En Year: 2021 Type: Article