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Genome-wide CRISPR-Cas9 knockout library screening identified PTPMT1 in cardiolipin synthesis is crucial to survival in hypoxia in liver cancer.
Bao, Macus Hao-Ran; Yang, Chunxue; Tse, Aki Pui-Wah; Wei, Lai; Lee, Derek; Zhang, Misty Shuo; Goh, Chi Ching; Chiu, David Kung-Chun; Yuen, Vincent Wai-Hin; Law, Cheuk-Ting; Chin, Wai-Ching; Chui, Noreen Nog-Qin; Wong, Bowie Po-Yee; Chan, Cerise Yuen-Ki; Ng, Irene Oi-Lin; Chung, Clive Yik-Sham; Wong, Chun-Ming; Wong, Carmen Chak-Lui.
Affiliation
  • Bao MH; Department of Pathology, The University of Hong Kong, Hong Kong.
  • Yang C; Department of Pathology, The University of Hong Kong, Hong Kong.
  • Tse AP; Department of Pathology, The University of Hong Kong, Hong Kong.
  • Wei L; Department of Pathology, The University of Hong Kong, Hong Kong.
  • Lee D; Department of Pathology, The University of Hong Kong, Hong Kong.
  • Zhang MS; Department of Pathology, The University of Hong Kong, Hong Kong.
  • Goh CC; Department of Pathology, The University of Hong Kong, Hong Kong.
  • Chiu DK; Department of Pathology, The University of Hong Kong, Hong Kong.
  • Yuen VW; Department of Pathology, The University of Hong Kong, Hong Kong.
  • Law CT; Department of Pathology, The University of Hong Kong, Hong Kong.
  • Chin WC; Department of Pathology, The University of Hong Kong, Hong Kong.
  • Chui NN; Department of Pathology, The University of Hong Kong, Hong Kong.
  • Wong BP; Department of Pathology, The University of Hong Kong, Hong Kong.
  • Chan CY; Department of Pathology, The University of Hong Kong, Hong Kong.
  • Ng IO; Department of Pathology, The University of Hong Kong, Hong Kong; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong.
  • Chung CY; Department of Pathology, The University of Hong Kong, Hong Kong; School of Biomedical Sciences, The University of Hong Kong, Hong Kong.
  • Wong CM; Department of Pathology, The University of Hong Kong, Hong Kong; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong. Electronic address: jackwong@pathology.hku.hk.
  • Wong CC; Department of Pathology, The University of Hong Kong, Hong Kong; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong. Electronic address: carmencl@pathology.hku.hk.
Cell Rep ; 34(4): 108676, 2021 01 26.
Article in En | MEDLINE | ID: mdl-33503428
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Full text: 1 Database: MEDLINE Main subject: Cardiolipins / PTEN Phosphohydrolase / Liver Neoplasms Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Animals / Humans / Male Language: En Year: 2021 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Cardiolipins / PTEN Phosphohydrolase / Liver Neoplasms Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Animals / Humans / Male Language: En Year: 2021 Type: Article