Dysfunctional EGFR and oxidative stress-induced PKD1 signaling drive formation of DCLK1+ pancreatic stem cells.

Fleming Martinez, Alicia K; Döppler, Heike R; Bastea, Ligia I; Edenfield, Brandy; Patel, Tushar; Leitges, Michael; Liou, Geou-Yarh; Storz, Peter.

Affiliation

Fleming Martinez AK; Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Jacksonville, FL 32224, USA.
Döppler HR; Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Jacksonville, FL 32224, USA.
Bastea LI; Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Jacksonville, FL 32224, USA.
Edenfield B; Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Jacksonville, FL 32224, USA.
Patel T; Department of Transplantation, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Jacksonville, FL 32224, USA.
Leitges M; Division of Biomedical Sciences/Faculty of Medicine, Craig L Dobbin Genetics Research Centre, Memorial University of Newfoundland, St. John`s, Newfoundland A1B 3V6, Canada.
Liou GY; Department of Biological Sciences, Center for Cancer Research & Therapeutic Development, Clark Atlanta University, Atlanta, GA 30314, USA.
Storz P; Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Jacksonville, FL 32224, USA.

iScience ; 24(1): 102019, 2021 Jan 22.

Article in En | MEDLINE | ID: mdl-33521594