Melatonin: From Pharmacokinetics to Clinical Use in Autism Spectrum Disorder.

Lalanne, Sébastien; Fougerou-Leurent, Claire; Anderson, George M; Schroder, Carmen M; Nir, Tali; Chokron, Sylvie; Delorme, Richard; Claustrat, Bruno; Bellissant, Eric; Kermarrec, Solenn; Franco, Patricia; Denis, Laure; Tordjman, Sylvie

Lalanne, Sébastien; Fougerou-Leurent, Claire; Anderson, George M; Schroder, Carmen M; Nir, Tali; Chokron, Sylvie; Delorme, Richard; Claustrat, Bruno; Bellissant, Eric; Kermarrec, Solenn; Franco, Patricia; Denis, Laure; Tordjman, Sylvie.

Affiliation

Lalanne S; Experimental and Clinical Pharmacology Department, CHU Rennes, 35033 Rennes, France.
Fougerou-Leurent C; Inserm, CIC 1414 (Clinical Investigation Center), 35033 Rennes, France.
Anderson GM; Experimental and Clinical Pharmacology Department, CHU Rennes, 35033 Rennes, France.
Schroder CM; Inserm, CIC 1414 (Clinical Investigation Center), 35033 Rennes, France.
Nir T; Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA.
Chokron S; Department of Child and Adolescent Psychiatry, Strasbourg University Hospitals, 67000 Strasbourg, France.
Delorme R; CNRS UPR 3212, Institute for Cellular and Integrative Neurosciences, 67000 Strasbourg, France.
Claustrat B; Sleep Disorders Center & CIRCSom (International Research Center for ChronoSomnology), Strasbourg University Hospital, 67000 Strasbourg, France.
Bellissant E; Neurim Pharmaceuticals Ltd., Tel Aviv 69710, Israel.
Kermarrec S; Integrative Neuroscience and Cognition Center (INCC), CNRS UMR 8002 and University of Paris, 75006 Paris, France.
Franco P; Child and Adolescent Psychiatry Department, Robert Debré Hospital and University of Paris, 75019 Paris, France.
Denis L; Laboratoire d'Hormonologie, Inserm U846, Centre de Médecine Nucléaire, Hospices Civils de Lyon, 69677 Bron, France.
Tordjman S; Experimental and Clinical Pharmacology Department, CHU Rennes, 35033 Rennes, France.

Int J Mol Sci ; 22(3)2021 Feb 02.

Article in En | MEDLINE | ID: mdl-33540815

Subject(s)

Autism Spectrum Disorder/complications; Melatonin/pharmacokinetics; Sleep Disorders, Intrinsic/drug therapy; Administration, Oral; Adult; Autism Spectrum Disorder/metabolism; Autism Spectrum Disorder/psychology; Biological Availability; Child; Child, Preschool; Circadian Rhythm; Delayed-Action Preparations; Dietary Supplements; Female; Humans; Injections, Intravenous; Male; Melatonin/administration & dosage; Melatonin/analogs & derivatives; Melatonin/physiology; Melatonin/therapeutic use; Melatonin/urine; Receptors, Melatonin/physiology; Saliva/chemistry; Seasons; Serotonin/metabolism; Sleep Disorders, Intrinsic/etiology; Sleep Disorders, Intrinsic/physiopathology; Sleep Latency/drug effects; Social Behavior Disorders/drug therapy; Social Behavior Disorders/etiology; Tryptophan/metabolism

Key words

analytical variability; autism; autism spectrum disorder (ASD); autistic behavioral impairments; circadian rhythm; concentration-effect relationship; dose-response effect; melatonin; pharmacokinetics; tolerability

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Full text: 1 Database: MEDLINE Main subject: Sleep Disorders, Intrinsic / Autism Spectrum Disorder / Melatonin Type of study: Etiology_studies Limits: Adult / Child / Child, preschool / Female / Humans / Male Language: En Year: 2021 Type: Article

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