Antidepressant-like effect of ethanol in mice forced swimming test is mediated via inhibition of NMDA/nitric oxide/cGMP signaling pathway.

Khan, Muhammad Imran; Nikoui, Vahid; Naveed, Aamir; Mumtaz, Faiza; Zaman, Hamid; Haider, Adnan; Aman, Waqar; Wahab, Abdul; Khan, Shahid Niaz; Ullah, Najeeb; Dehpour, Ahmad Reza

Khan, Muhammad Imran; Nikoui, Vahid; Naveed, Aamir; Mumtaz, Faiza; Zaman, Hamid; Haider, Adnan; Aman, Waqar; Wahab, Abdul; Khan, Shahid Niaz; Ullah, Najeeb; Dehpour, Ahmad Reza.

Affiliation

Khan MI; Riphah Institute of Pharmaceutical Sciences, Riphah International University, G7-Islamabad, Pakistan; Department of Pharmacy, Kohat University of Science and Technology, Kohat, 26000, KPK, Pakistan. Electronic address: dr.imrankhan@riphah.edu.pk.
Nikoui V; Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.
Naveed A; Department of Psychiatry, PIMS, Islamabad, Pakistan.
Mumtaz F; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Zaman H; Department of Pharmacy, Kohat University of Science and Technology, Kohat, 26000, KPK, Pakistan.
Haider A; Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Punjab, 46000, Pakistan.
Aman W; Faculty of Pharmacy, University of Central Punjab, Lahore, Punjab, Pakistan.
Wahab A; Department of Pharmacy, Kohat University of Science and Technology, Kohat, 26000, KPK, Pakistan.
Khan SN; Department of Zoology, Kohat University of Science & Technology, Kohat, Pakistan.
Ullah N; Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, KPK, Pakistan.
Dehpour AR; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: dehpour@sina.tums.ac.ir.

Alcohol ; 92: 53-63, 2021 05.

Article in En | MEDLINE | ID: mdl-33581263

Subject(s)

Swimming; Animals; Antidepressive Agents/pharmacology; Arginine/pharmacology; Cyclic GMP; Depression/drug therapy; Ethanol/pharmacology; Mice; N-Methylaspartate/pharmacology; Nitric Oxide/metabolism; Receptors, N-Methyl-D-Aspartate/metabolism; Signal Transduction/drug effects

Key words

NMDA; depression; ethanol; forced swimming test (FST); mice; nitric oxide cyclic-guanosine monophosphate (NO-cGMP)

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