Beyond Standard Practice in Liquid Biopsy: Selective Venous Sampling.
J Vasc Interv Radiol
; 32(5): 668-671, 2021 05.
Article
in En
| MEDLINE
| ID: mdl-33621662
ABSTRACT
Liquid biopsy is a molecular diagnostic procedure that aims to provide readily accessible genetic profiling of tumors for primary diagnosis, detection of minimal residual or metastatic disease, and therapeutic decision-making, especially for molecularly targeted treatments. Cancers release various biological markers into the circulation, although the most widely used are cell-free tumor DNA and circulating tumor cells. The paucity of biological material means that laboratory methods mainly based on genetic sequencing expose this innovative diagnostic method to a considerable incidence of false negatives. The 3 cases presented here show how the sensitivity and specificity of liquid biopsy may be improved through selective venous sampling.
Full text:
1
Database:
MEDLINE
Main subject:
Biomarkers, Tumor
/
Molecular Diagnostic Techniques
/
Circulating Tumor DNA
/
Liquid Biopsy
/
Neoplastic Cells, Circulating
/
Neoplasms
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
En
Year:
2021
Type:
Article