FOS Rearrangement and Expression in Cementoblastoma.
Am J Surg Pathol
; 45(5): 690-693, 2021 05 01.
Article
in En
| MEDLINE
| ID: mdl-33653978
ABSTRACT
Cementoblastomas are rare odontogenic tumors developing in close proximity to the roots of teeth. Due to their striking morphologic resemblance to osteoblastomas of the peripheral skeleton, we set out to determine whether cementoblastomas harbor the same FOS rearrangements with overexpression of c-FOS as has recently been described for osteoblastomas. In total, 16 cementoblastomas were analyzed for FOS expression by immunohistochemistry and for FOS rearrangements by fluorescence in situ hybridization (FISH). We observed strong and diffuse staining of c-FOS in 71% of cementoblastomas and identified a FOS rearrangement in all cases (n=3) applicable for FISH. In the remaining cases, FISH failed due to decalcification. Cementoblastomas harbor similar FOS rearrangements and show overexpression of c-FOS like osteoblastomas, suggesting that both entities might represent parts of the spectrum of the same disease.
Full text:
1
Database:
MEDLINE
Main subject:
Tooth Root
/
Bone Neoplasms
/
Gene Rearrangement
/
Odontogenic Tumors
/
Biomarkers, Tumor
/
Proto-Oncogene Proteins c-fos
/
Osteoblastoma
/
Dental Cementum
Type of study:
Clinical_trials
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Year:
2021
Type:
Article