Antifungal activity of nikkomycin Z against Candida auris.
J Antimicrob Chemother
; 76(6): 1495-1497, 2021 05 12.
Article
in En
| MEDLINE
| ID: mdl-33677578
ABSTRACT
BACKGROUND:
Nikkomycin Z is a competitive inhibitor of chitin synthase-an enzyme needed for synthesis of the fungal cell wall. Nikkomycin Z shows promise as a treatment for coccidioidomycoses and mixed activity has been described against other fungi and yeast. To our knowledge, it has not previously been tested against the emerging fungal pathogen Candida auris.OBJECTIVES:
To determine the in vitro activity of nikkomycin Z against C. auris.METHODS:
Nikkomycin Z was tested by broth microdilution against a panel of 100 isolates of genetically diverse C. auris from around the world.RESULTS:
Nikkomycin Z showed mixed activity against the tested isolates, with an MIC range of 0.125 to >64 mg/L. The MIC50 and MIC90 were 2 and 32 mg/L, respectively.CONCLUSIONS:
These findings suggest nikkomycin Z has in vitro activity against some, but not all isolates of C. auris.
Full text:
1
Database:
MEDLINE
Main subject:
Candida
/
Antifungal Agents
Language:
En
Year:
2021
Type:
Article