Dendritic Cell Regulation of T Helper Cells.
Annu Rev Immunol
; 39: 759-790, 2021 04 26.
Article
in En
| MEDLINE
| ID: mdl-33710920
ABSTRACT
As the professional antigen-presenting cells of the immune system, dendritic cells (DCs) sense the microenvironment and shape the ensuing adaptive immune response. DCs can induce both immune activation and immune tolerance according to the peripheral cues. Recent work has established that DCs comprise several phenotypically and functionally heterogeneous subsets that differentially regulate T lymphocyte differentiation. This review summarizes both mouse and human DC subset phenotypes, development, diversification, and function. We focus on advances in our understanding of how different DC subsets regulate distinct CD4+ T helper (Th) cell differentiation outcomes, including Th1, Th2, Th17, T follicular helper, and T regulatory cells. We review DC subset intrinsic properties, local tissue microenvironments, and other immune cells that together determine Th cell differentiation during homeostasis and inflammation.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Lymphocyte Activation
/
Immune Tolerance
Limits:
Animals
/
Humans
Language:
En
Year:
2021
Type:
Article