Digestion of Lipid-Based Formulations Not Only Mediates Changes to Absorption of Poorly Soluble Drugs Due to Differences in Solubilization But Also Reflects Changes to Thermodynamic Activity and Permeability.

Tanaka, Yusuke; Nguyen, Tri-Hung; Suys, Estelle J A; Porter, Christopher J H

Tanaka, Yusuke; Nguyen, Tri-Hung; Suys, Estelle J A; Porter, Christopher J H.

Affiliation

Tanaka Y; Laboratory of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hiro-koshingai, Kure, Hiroshima 737-0112, Japan.

Mol Pharm ; 18(4): 1768-1778, 2021 04 05.

Article in En | MEDLINE | ID: mdl-33729806

Subject(s)

Excipients/chemistry; Lipids/chemistry; Saquinavir/pharmacokinetics; Administration, Oral; Animals; Area Under Curve; Body Fluids/chemistry; Chemistry, Pharmaceutical; Gastrointestinal Absorption; Intestinal Absorption; Male; Models, Animal; Permeability; Rats; Saquinavir/administration & dosage; Saquinavir/chemistry; Solubility

Key words

fatty acids; free concentration; in vitro digestion; lipid-based formulation; oral absorption

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Full text: 1 Database: MEDLINE Main subject: Saquinavir / Excipients / Lipids Type of study: Prognostic_studies Limits: Animals Language: En Year: 2021 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Saquinavir / Excipients / Lipids Type of study: Prognostic_studies Limits: Animals Language: En Year: 2021 Type: Article