Novel Molecular Insights into Human Lipid-Mediated T Cell Immunity.
Int J Mol Sci
; 22(5)2021 Mar 05.
Article
in En
| MEDLINE
| ID: mdl-33807663
ABSTRACT
T cells represent a critical arm of our immune defense against pathogens. Over the past two decades, considerable inroads have been made in understanding the fundamental principles underpinning the molecular presentation of peptide-based antigens by the Major Histocompatibility Complex molecules (MHC-I and II), and their molecular recognition by specialized subsets of T cells. However, some T cells can recognize lipid-based antigens presented by MHC-I-like molecules that belong to the Cluster of Differentiation 1 (CD1) family. Here, we will review the advances that have been made in the last five years to understand the molecular mechanisms orchestrating the presentation of novel endogenous and exogenous lipid-based antigens by the CD1 glycoproteins and their recognition by specific populations of CD1-reactive T cells.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Lymphocyte Activation
/
T-Lymphocytes
/
Histocompatibility Antigens Class I
/
Antigens, CD1
/
Lipids
/
Antigens
Limits:
Humans
Language:
En
Year:
2021
Type:
Article