Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype.

Chen, David Y; Ferguson, Ian M; Braun, Krista A; Sutton, Leslie A; Helton, Nichole M; Ramakrishnan, Sai Mukund; Smith, Amanda M; Miller, Christopher A; Ley, Timothy J

Chen, David Y; Ferguson, Ian M; Braun, Krista A; Sutton, Leslie A; Helton, Nichole M; Ramakrishnan, Sai Mukund; Smith, Amanda M; Miller, Christopher A; Ley, Timothy J.

Affiliation

Chen DY; Division of Dermatology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110.
Ferguson IM; Division of Dermatology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110.
Braun KA; Division of Dermatology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110.
Sutton LA; Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110.
Helton NM; Division of Dermatology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110.
Ramakrishnan SM; Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110.
Smith AM; Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110.
Miller CA; Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110.
Ley TJ; Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110.

Proc Natl Acad Sci U S A ; 118(16)2021 04 20.

Article in En | MEDLINE | ID: mdl-33846253

Subject(s)

DNA Methylation/physiology; DNA Methyltransferase 3A/genetics; Keratinocytes/metabolism; Abnormalities, Multiple/genetics; Adolescent; Animals; Child; DNA/metabolism; DNA (Cytosine-5-)-Methyltransferases/genetics; DNA Methyltransferase 3A/metabolism; DNA Modification Methylases/metabolism; Germ-Line Mutation; Heterozygote; Humans; Intellectual Disability/genetics; Keratinocytes/physiology; Male; Methyltransferases/genetics; Mice; Mutation; Phenotype; Skin/metabolism; Syndrome

Key words

DNA methylation; DNMT3A; epidermis; epigenetic; premalignant

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Full text: 1 Database: MEDLINE Main subject: Keratinocytes / DNA Methylation / DNA Methyltransferase 3A Type of study: Etiology_studies / Prognostic_studies Limits: Adolescent / Animals / Child / Humans / Male Language: En Year: 2021 Type: Article

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