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Direct Synthesis of N-Difluoromethyl-2-pyridones from Pyridines.
Zhou, Sen; Hou, Xiaoya; Yang, Kai; Guo, Minjie; Zhao, Wentao; Tang, Xiangyang; Wang, Guangwei.
Affiliation
  • Zhou S; Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, P. R. China.
  • Hou X; Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, P. R. China.
  • Yang K; Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, P. R. China.
  • Guo M; Institute for Molecular Design and Synthesis, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, P. R. China.
  • Zhao W; Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, P. R. China.
  • Tang X; Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, P. R. China.
  • Wang G; Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, P. R. China.
J Org Chem ; 86(9): 6879-6887, 2021 05 07.
Article in En | MEDLINE | ID: mdl-33905251
ABSTRACT
A novel method for the synthesis of N-difluoromethyl-2-pyridones was described. This protocol enables the synthesis of N-difluoromethyl-2-pyridones from readily available pyridines using mild reaction conditions that are compatible with a wide range of functional groups. The preliminary mechanistic study revealed that N-difluoromethylpyridinium salts were the key intermediates to complete this conversion.
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Full text: 1 Database: MEDLINE Main subject: Pyridines / Pyridones Language: En Year: 2021 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Pyridines / Pyridones Language: En Year: 2021 Type: Article