Highly Sensitive and Cost-Effective Portable Sensor for Early Gastric Carcinoma Diagnosis.
Sensors (Basel)
; 21(8)2021 Apr 09.
Article
in En
| MEDLINE
| ID: mdl-33918707
ABSTRACT
Facile and efficient early detection of cancer is a major challenge in healthcare. Herein we developed a novel sensor made from a polycarbonate (PC) membrane with nanopores, followed by sequence-specific Oligo RNA modification for early gastric carcinoma diagnosis. In this design, the gastric cancer antigen CA72-4 is specifically conjugated to the Oligo RNA, thereby inhibiting the electrical current through the PC membrane in a concentration-dependent manner. The device can determine the concentration of cancer antigen CA72-4 in the range from 4 to 14 U/mL, possessing a sensitivity of 7.029 µAU-1mLcm-2 with a linear regression (R2) of 0.965 and a lower detection limit of 4 U/mL. This device has integrated advantages including high specificity and sensitivity and being simple, portable, and cost effective, which collectively enables a giant leap for cancer screening technologies towards clinical use. This is the first report to use RNA aptamers to detect CA72-4 for gastric carcinoma diagnosis.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Stomach Neoplasms
/
Carcinoma
Type of study:
Diagnostic_studies
/
Health_economic_evaluation
/
Screening_studies
Limits:
Humans
Language:
En
Year:
2021
Type:
Article