6,7,4'-Trihydroxyflavanone Mitigates Methamphetamine-Induced Neurotoxicity in SH-SY5y Cells via Nrf2/heme Oxyganase-1 and PI3K/Akt/mTOR Signaling Pathways.

Lee, Hyun-Su; Jeong, Gil-Saeng

Lee, Hyun-Su; Jeong, Gil-Saeng.

Affiliation

Lee HS; College of Pharmacy, Keimyung University, Daegu 42601, Korea.
Jeong GS; College of Pharmacy, Keimyung University, Daegu 42601, Korea.

Molecules ; 26(9)2021 Apr 22.

Article in En | MEDLINE | ID: mdl-33922144

Subject(s)

Flavanones/pharmacology; Heme Oxygenase-1/metabolism; Methamphetamine/adverse effects; NF-E2-Related Factor 2/metabolism; Neuroprotective Agents/pharmacology; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; TOR Serine-Threonine Kinases/metabolism; Apoptosis/drug effects; Cell Line, Tumor; Humans; Neurons/drug effects; Neurons/metabolism; Oxidative Stress; Phosphorylation; Signal Transduction/drug effects

Key words

6,7,4'-trihydroxyflavanone; HO-1; Nrf2; PI3K; SH-SY5y cells; methamphetamine; neurotoxicity

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Full text: 1 Database: MEDLINE Main subject: Neuroprotective Agents / Phosphatidylinositol 3-Kinases / Flavanones / Heme Oxygenase-1 / Proto-Oncogene Proteins c-akt / NF-E2-Related Factor 2 / TOR Serine-Threonine Kinases / Methamphetamine Limits: Humans Language: En Year: 2021 Type: Article

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