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Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction.
Albiñana, Clara; Grove, Jakob; McGrath, John J; Agerbo, Esben; Wray, Naomi R; Bulik, Cynthia M; Nordentoft, Merete; Hougaard, David M; Werge, Thomas; Børglum, Anders D; Mortensen, Preben Bo; Privé, Florian; Vilhjálmsson, Bjarni J.
Affiliation
  • Albiñana C; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210 Aarhus V, Denmark; National Centre for Register-Based Research, Aarhus University, 8210 Aarhus V, Denmark. Electronic address: albinanaclara@gmail.com.
  • Grove J; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210 Aarhus V, Denmark; Department of Biomedicine and Center for Integrative Sequencing, iSEQ, Aarhus University, 8000 Aarhus C, Denmark; Center for Genomics and Personalized Medicine, CGPM, Aarhus University, 8000 Aarh
  • McGrath JJ; National Centre for Register-Based Research, Aarhus University, 8210 Aarhus V, Denmark; Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Brisbane, QLD 4076, Australia; Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
  • Agerbo E; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210 Aarhus V, Denmark; National Centre for Register-Based Research, Aarhus University, 8210 Aarhus V, Denmark.
  • Wray NR; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia; Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
  • Bulik CM; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
  • Nordentoft M; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210 Aarhus V, Denmark; Copenhagen University Hospital, Mental Health Centre Copenhagen Mental Health Services in the Capital Region of Denmark, 2100 Copenhagen Ø, Denmark; Department of Clinical Medicine, University of
  • Hougaard DM; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210 Aarhus V, Denmark; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, 2300 Copenhagen S, Denmark.
  • Werge T; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210 Aarhus V, Denmark; Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, 4000 Roskilde, Denmark; Department of Clinical Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark
  • Børglum AD; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210 Aarhus V, Denmark; Department of Biomedicine and Center for Integrative Sequencing, iSEQ, Aarhus University, 8000 Aarhus C, Denmark; Center for Genomics and Personalized Medicine, CGPM, Aarhus University, 8000 Aarh
  • Mortensen PB; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210 Aarhus V, Denmark; National Centre for Register-Based Research, Aarhus University, 8210 Aarhus V, Denmark.
  • Privé F; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210 Aarhus V, Denmark; National Centre for Register-Based Research, Aarhus University, 8210 Aarhus V, Denmark.
  • Vilhjálmsson BJ; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210 Aarhus V, Denmark; National Centre for Register-Based Research, Aarhus University, 8210 Aarhus V, Denmark; Bioinformatics Research Centre, Aarhus University, 8000 Aarhus C, Denmark. Electronic address: bjv@econ.au.
Am J Hum Genet ; 108(6): 1001-1011, 2021 06 03.
Article in En | MEDLINE | ID: mdl-33964208
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Full text: 1 Database: MEDLINE Main subject: Disease / Models, Statistical / Genetic Predisposition to Disease / Multifactorial Inheritance / Polymorphism, Single Nucleotide / Genome-Wide Association Study Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Year: 2021 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Disease / Models, Statistical / Genetic Predisposition to Disease / Multifactorial Inheritance / Polymorphism, Single Nucleotide / Genome-Wide Association Study Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Year: 2021 Type: Article