Your browser doesn't support javascript.
loading
Mechanism of Action of Peripheral Nerve Stimulation.
Strand, Natalie H; D'Souza, Ryan; Wie, Christopher; Covington, Stephen; Maita, Moustafa; Freeman, John; Maloney, Jillian.
Affiliation
  • Strand NH; Department of Anesthesiology, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA. strand.natalie@mayo.edu.
  • D'Souza R; Department of Anesthesiology, Mayo Clinic Minnesota, Rochester, MN, USA.
  • Wie C; Department of Anesthesiology, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.
  • Covington S; Department of Physician Medicine and Rehabilitation, Mayo Clinic Minnesota, Rochester, MN, USA.
  • Maita M; Department of Anesthesiology, University of Texas Health Sciences Center San Antonio, San Antonio, TX, USA.
  • Freeman J; Department of Anesthesiology, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.
  • Maloney J; Department of Anesthesiology, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.
Curr Pain Headache Rep ; 25(7): 47, 2021 May 11.
Article in En | MEDLINE | ID: mdl-33973135
ABSTRACT
PURPOSE OF REVIEW The number of applications for peripheral nerve stimulation (PNS) in the pain management field is ever-growing. With the increasing number of clinical applications for peripheral nerve stimulation, the purpose of this article is to review the mechanism of action surrounding PNS, the recent literature from January 2018 to January 2021, and pertinent clinical outcomes. RECENT

FINDINGS:

The authors searched articles identified from PubMed (January 2018-January 2021), Cochrane Central Register of Controlled Trials databases (January 2018-January 2021), and Scopus (January 2018-January 2021) databases, and manually searched references of identified publications. Broad MeSH terms and Boolean operators were queried in each search, including the following terms and their respective synonyms peripheral nerve stimulation, mechanism of action, biochemical pathway, and pain pathway. 15 consensus articles were selected for in-depth review and inclusion for qualitative analysis. PNS may activate and modulate higher central nervous system (CNS) centers, including the dorsal lateral prefrontal cortex, somatosensory cortex, anterior cingulate cortex, and parahippocampal areas. Neuromodulatory effects from PNS may also extend into the spinal columns. Also, PNS may lead to changes in endogenous neurotransmitters and affect the plasticity of NMDA pathways.
Subject(s)
Key words

Full text: 1 Database: MEDLINE Main subject: Peripheral Nerves / Transcutaneous Electric Nerve Stimulation Type of study: Prognostic_studies / Qualitative_research Limits: Humans Language: En Year: 2021 Type: Article

Full text: 1 Database: MEDLINE Main subject: Peripheral Nerves / Transcutaneous Electric Nerve Stimulation Type of study: Prognostic_studies / Qualitative_research Limits: Humans Language: En Year: 2021 Type: Article