Effect of Daikenchuto On Spontaneous Intestinal Tumors in ApcMin/+ Mice.
Kobe J Med Sci
; 66(4): E139-E148, 2021 Jan 04.
Article
in En
| MEDLINE
| ID: mdl-33994517
ABSTRACT
Daikenchuto (TU-100) is herbal medicine which predominantly contains ginger, Japanese pepper, and ginseng. We investigated whether TU-100 can affect the composition of gut flora and intestinal tumor development using ApcMin/+ mice, a murine model of intestinal tumor. Bacterial 16S rRNA sequencing and short-chain fatty acid analysis were performed on faecal samples. Tumor number and size were analysed. Any change in gene expression of the tumor tissues was assessed by real-time PCR. Principal coordinate analysis (PCoA) showed that the faecal microbiota cluster of TU-100-fed mice was different from the microbiota of control mice. However, no significant difference was observed in the concentration of short-chain fatty acids, tumor number, and gene expression levels between the two groups. Our data showed that TU-100 can affect the intestinal environment; however, it does not contribute in tumor progression or inhibition in our setting.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Plant Extracts
/
Herbal Medicine
/
Gastrointestinal Microbiome
/
Intestinal Mucosa
/
Intestinal Neoplasms
Limits:
Animals
Language:
En
Year:
2021
Type:
Article