Elementary mechanisms of calmodulin regulation of Na<sub>V</sub>1.5 producing divergent arrhythmogenic phenotypes.

Kang, Po Wei; Chakouri, Nourdine; Diaz, Johanna; Tomaselli, Gordon F; Yue, David T; Ben-Johny, Manu

Elementary mechanisms of calmodulin regulation of Na_V1.5 producing divergent arrhythmogenic phenotypes.

Kang, Po Wei; Chakouri, Nourdine; Diaz, Johanna; Tomaselli, Gordon F; Yue, David T; Ben-Johny, Manu.

Affiliation

Kang PW; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218; kang.powei@wustl.edu mbj2124@cumc.columbia.edu.
Chakouri N; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130.
Diaz J; Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032.
Tomaselli GF; Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032.
Yue DT; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461.
Ben-Johny M; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218.

Proc Natl Acad Sci U S A ; 118(21)2021 05 25.

Article in En | MEDLINE | ID: mdl-34021086

Subject(s)

Action Potentials/genetics; Calcium/metabolism; Calmodulin/chemistry; Myocytes, Cardiac/metabolism; NAV1.5 Voltage-Gated Sodium Channel/chemistry; Arrhythmias, Cardiac/genetics; Arrhythmias, Cardiac/metabolism; Arrhythmias, Cardiac/pathology; Binding Sites; Calcium Signaling; Calmodulin/genetics; Calmodulin/metabolism; Fluorescence Resonance Energy Transfer; Gene Expression; HEK293 Cells; Humans; Ion Channel Gating; Kinetics; Models, Molecular; Mutation; Myocytes, Cardiac/cytology; NAV1.5 Voltage-Gated Sodium Channel/genetics; NAV1.5 Voltage-Gated Sodium Channel/metabolism; Patch-Clamp Techniques; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Sodium/metabolism

Key words

Brugada syndrome; Nav1.5; calmodulin; ion channels; long QT syndrome

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Full text: 1 Database: MEDLINE Main subject: Action Potentials / Calmodulin / Calcium / Myocytes, Cardiac / NAV1.5 Voltage-Gated Sodium Channel Type of study: Prognostic_studies Limits: Humans Language: En Year: 2021 Type: Article

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