Clonal Cytopenia of Undetermined Significance in a Patient with Congenital Wilms' Tumor 1 and Acquired DNMT3A Gene Mutations.
Intern Med
; 60(23): 3785-3788, 2021 Dec 01.
Article
in En
| MEDLINE
| ID: mdl-34053991
ABSTRACT
Congenital mutations of the Wilms' tumor 1 (WT1) gene can lead to various abnormalities, including renal/gonadal developmental disorders and cardiac malformations. Although there have been many reports of somatic WT1 mutations in patients with acute myeloid leukemia and myelodysplastic syndrome, congenital WT1 mutations have not been reported in hematological disorders. We herein report a patient with early-onset clonal cytopenia of undetermined significance that was associated with a congenital mutation of WT1 and an acquired mutation of DNMT3A [encoding DNA (cytosine-5)-methyltransferase 3A].
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Wilms Tumor
/
Clonal Hematopoiesis
/
DNA Methyltransferase 3A
/
Kidney Neoplasms
Limits:
Humans
Language:
En
Year:
2021
Type:
Article