ATM: Main Features, Signaling Pathways, and Its Diverse Roles in DNA Damage Response, Tumor Suppression, and Cancer Development.
Genes (Basel)
; 12(6)2021 05 30.
Article
in En
| MEDLINE
| ID: mdl-34070860
ABSTRACT
ATM is among of the most critical initiators and coordinators of the DNA-damage response. ATM canonical and non-canonical signaling pathways involve hundreds of downstream targets that control many important cellular processes such as DNA damage repair, apoptosis, cell cycle arrest, metabolism, proliferation, oxidative sensing, among others. Of note, ATM is often considered a major tumor suppressor because of its ability to induce apoptosis and cell cycle arrest. However, in some advanced stage tumor cells, ATM signaling is increased and confers remarkable advantages for cancer cell survival, resistance to radiation and chemotherapy, biosynthesis, proliferation, and metastasis. This review focuses on addressing major characteristics, signaling pathways and especially the diverse roles of ATM in cellular homeostasis and cancer development.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Carcinogenesis
/
Ataxia Telangiectasia Mutated Proteins
Limits:
Animals
/
Humans
Language:
En
Year:
2021
Type:
Article