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Synthesis and evaluation of adenosine derivatives as A1, A2A, A2B and A3 adenosine receptor ligands containing boron clusters as phenyl isosteres and selective A3 agonists.
Bednarska-Szczepaniak, Katarzyna; Mieczkowski, Adam; Kierozalska, Aleksandra; Pavlovic Saftic, Dijana; Glabala, Konrad; Przygodzki, Tomasz; Stanczyk, Lidia; Karolczak, Kamil; Watala, Cezary; Rao, Harsha; Gao, Zhan-Guo; Jacobson, Kenneth A; Lesnikowski, Zbigniew J.
Affiliation
  • Bednarska-Szczepaniak K; Laboratory of Medicinal Chemistry, Institute of Medical Biology PAS, Lodowa 106, 92-232, Lódz, Poland.
  • Mieczkowski A; Laboratory of Biological Chemistry of Metal Ions, Institute of Biochemistry and Biophysics PAS, Pawinskiego 5a, 02-106, Warsaw, Poland.
  • Kierozalska A; Laboratory of Medicinal Chemistry, Institute of Medical Biology PAS, Lodowa 106, 92-232, Lódz, Poland.
  • Pavlovic Saftic D; Laboratory of Medicinal Chemistry, Institute of Medical Biology PAS, Lodowa 106, 92-232, Lódz, Poland.
  • Glabala K; Laboratory of Medicinal Chemistry, Institute of Medical Biology PAS, Lodowa 106, 92-232, Lódz, Poland.
  • Przygodzki T; Department of Haemostatic Disorders, Medical University of Lodz, 6/8 Mazowiecka St. 92-215, Lodz, Poland.
  • Stanczyk L; Department of Haemostatic Disorders, Medical University of Lodz, 6/8 Mazowiecka St. 92-215, Lodz, Poland.
  • Karolczak K; Department of Haemostatic Disorders, Medical University of Lodz, 6/8 Mazowiecka St. 92-215, Lodz, Poland.
  • Watala C; Department of Haemostatic Disorders, Medical University of Lodz, 6/8 Mazowiecka St. 92-215, Lodz, Poland.
  • Rao H; Laboratory of Bioorganic Chemistry and Molecular Recognition Section, National Institute of Diabetes & Digestive & Kidney Diseases, NIH, Bethesda, MD, 20892-0810, USA.
  • Gao ZG; Laboratory of Bioorganic Chemistry and Molecular Recognition Section, National Institute of Diabetes & Digestive & Kidney Diseases, NIH, Bethesda, MD, 20892-0810, USA.
  • Jacobson KA; Laboratory of Bioorganic Chemistry and Molecular Recognition Section, National Institute of Diabetes & Digestive & Kidney Diseases, NIH, Bethesda, MD, 20892-0810, USA.
  • Lesnikowski ZJ; Laboratory of Medicinal Chemistry, Institute of Medical Biology PAS, Lodowa 106, 92-232, Lódz, Poland. Electronic address: zlesnikowski@cbm.pan.pl.
Eur J Med Chem ; 223: 113607, 2021 Nov 05.
Article in En | MEDLINE | ID: mdl-34171656
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Full text: 1 Database: MEDLINE Main subject: Adenosine / Receptor, Adenosine A3 / Adenosine A3 Receptor Agonists Limits: Animals / Humans Language: En Year: 2021 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Adenosine / Receptor, Adenosine A3 / Adenosine A3 Receptor Agonists Limits: Animals / Humans Language: En Year: 2021 Type: Article