Identification of Fucosylated SERPINA1 as a Novel Plasma Marker for Pancreatic Cancer Using Lectin Affinity Capture Coupled with iTRAQ-Based Quantitative Glycoproteomics.

Wu, Chia-Chun; Lu, Yu-Ting; Yeh, Ta-Sen; Chan, Yun-Hsin; Dash, Srinivas; Yu, Jau-Song

Wu, Chia-Chun; Lu, Yu-Ting; Yeh, Ta-Sen; Chan, Yun-Hsin; Dash, Srinivas; Yu, Jau-Song.

Affiliation

Wu CC; Molecular Medicine Research Center, Chang Gung University, Taoyuan 33302, Taiwan.
Lu YT; Molecular Medicine Research Center, Chang Gung University, Taoyuan 33302, Taiwan.
Yeh TS; Department of General Surgery, Chang Gung Memorial Hospital, Linkou 33305, Taiwan.
Chan YH; College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Dash S; Department of General Surgery, Chang Gung Memorial Hospital, Linkou 33305, Taiwan.
Yu JS; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.

Int J Mol Sci ; 22(11)2021 Jun 04.

Article in En | MEDLINE | ID: mdl-34199928

Subject(s)

Biomarkers, Tumor/blood; Fucose/chemistry; Glycoproteins/blood; Lectins/chemistry; Pancreatic Neoplasms/diagnosis; Proteome/metabolism; alpha 1-Antitrypsin/blood; Case-Control Studies; Chromatography, Affinity; Female; Fucose/metabolism; Humans; Lectins/metabolism; Male; Mass Spectrometry; Middle Aged; Pancreatic Neoplasms/blood; Proteome/analysis; Survival Rate; alpha 1-Antitrypsin/chemistry

Key words

AAL; fucosylated SERPINA1; glycobiomarker; iTRAQ-based quantitative proteome; pancreatic cancer; plasma; reverse lectin-based ELISA

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Full text: 1 Database: MEDLINE Main subject: Pancreatic Neoplasms / Glycoproteins / Biomarkers, Tumor / Alpha 1-Antitrypsin / Proteome / Fucose / Lectins Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male / Middle aged Language: En Year: 2021 Type: Article

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