Matrix lumican endocytosed by immune cells controls receptor ligand trafficking to promote TLR4 and restrict TLR9 in sepsis.

Maiti, George; Frikeche, Jihane; Lam, Carly Yuen-Man; Biswas, Asim; Shinde, Vishal; Samanovic, Marie; Kagan, Jonathan C; Mulligan, Mark J; Chakravarti, Shukti

Maiti, George; Frikeche, Jihane; Lam, Carly Yuen-Man; Biswas, Asim; Shinde, Vishal; Samanovic, Marie; Kagan, Jonathan C; Mulligan, Mark J; Chakravarti, Shukti.

Affiliation

Maiti G; Department of Ophthalmology, New York University Grossman School of Medicine, New York, NY 10016.
Frikeche J; Division of Preclinical Pharmacology and Safety, Sangamo Therapeutics, Valbonne 06560, France.
Lam CY; Department of Ophthalmology, New York University Grossman School of Medicine, New York, NY 10016.
Biswas A; Department of Ophthalmology, New York University Grossman School of Medicine, New York, NY 10016.
Shinde V; Department of Ophthalmology, New York University Grossman School of Medicine, New York, NY 10016.
Samanovic M; Langone Vaccine Center, New York University, New York, NY 10016.
Kagan JC; Harvard Medical School and Division of Gastroenterology, Boston Children's Hospital, Boston, MA 02115.
Mulligan MJ; Langone Vaccine Center, New York University, New York, NY 10016.
Chakravarti S; Department of Ophthalmology, New York University Grossman School of Medicine, New York, NY 10016; shukti.chakravarti@nyumc.org.

Proc Natl Acad Sci U S A ; 118(27)2021 07 06.

Article in En | MEDLINE | ID: mdl-34215697

Subject(s)

Endocytosis; Extracellular Matrix/metabolism; Leukocytes/metabolism; Lumican/metabolism; Sepsis/metabolism; Toll-Like Receptor 4/metabolism; Toll-Like Receptor 9/metabolism; Adult; Animals; Caveolin 1/metabolism; Cell Membrane/metabolism; Disease Models, Animal; Endosomes/metabolism; Fibroblasts/metabolism; HEK293 Cells; Humans; Ligands; Lipopolysaccharide Receptors/metabolism; Macrophages/metabolism; Mice, Inbred C57BL; Models, Biological; Myeloid Differentiation Factor 88/metabolism; Oligodeoxyribonucleotides/metabolism; Omentum/pathology; Paracrine Communication; Peritoneum/pathology; Protein Binding; Protein Transport; Sepsis/microbiology

Key words

TLR; inflammation; lumican; macrophage; sepsis

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Full text: 1 Database: MEDLINE Main subject: Sepsis / Endocytosis / Toll-Like Receptor 9 / Toll-Like Receptor 4 / Extracellular Matrix / Lumican / Leukocytes Type of study: Prognostic_studies Limits: Adult / Animals / Humans Language: En Year: 2021 Type: Article

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