Role of the Staphylococcus aureus Extracellular Loop of GraS in Resistance to Distinct Human Defense Peptides in PMN and Invasive Cardiovascular infections.

Cheung, Ambrose L; Cho, Junho; Bayer, Arnold S; Yeaman, Michael R; Xiong, Yan Q; Donegan, Niles P; Mikheyeva, Irina V; Lee, Gi Yong; Yang, Soo-Jin

Cheung, Ambrose L; Cho, Junho; Bayer, Arnold S; Yeaman, Michael R; Xiong, Yan Q; Donegan, Niles P; Mikheyeva, Irina V; Lee, Gi Yong; Yang, Soo-Jin.

Affiliation

Cheung AL; Department of Microbiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Cho J; Department of Microbiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Bayer AS; The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Yeaman MR; Department of Medicine, Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, California, USA.
Xiong YQ; The David Geffen School of Medicine at UCLAgrid.471398.0, Los Angeles, California, USA.
Donegan NP; The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Mikheyeva IV; Department of Medicine, Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, California, USA.
Lee GY; The David Geffen School of Medicine at UCLAgrid.471398.0, Los Angeles, California, USA.
Yang SJ; Department of Medicine, Division of Molecular Medicine, Harbor-UCLA Medical Center, Torrance, California, USA.

Infect Immun ; 89(10): e0034721, 2021 09 16.

Article in En | MEDLINE | ID: mdl-34227840

Subject(s)

Bacterial Proteins/genetics; Cardiovascular Infections/metabolism; Cardiovascular Infections/microbiology; Drug Resistance, Bacterial/genetics; Methicillin-Resistant Staphylococcus aureus/genetics; Neutrophils/metabolism; Staphylococcal Infections/metabolism; Animals; Antimicrobial Cationic Peptides/metabolism; Endocarditis/metabolism; Endocarditis/microbiology; Female; Gene Expression Regulation, Bacterial/genetics; Humans; Microbial Sensitivity Tests/methods; Microbial Viability/genetics; Neutrophils/microbiology; Rabbits; Staphylococcal Infections/microbiology

Key words

GraRS; GraS membrane sensor; HA-MRSA; Staphylococcus aureus; cardiovascular infections; cationic host defense peptides (HDPs); pH response; two-component regulatory system (TCRS)

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Full text: 1 Database: MEDLINE Main subject: Staphylococcal Infections / Bacterial Proteins / Drug Resistance, Bacterial / Cardiovascular Infections / Methicillin-Resistant Staphylococcus aureus / Neutrophils Limits: Animals / Female / Humans Language: En Year: 2021 Type: Article

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