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Insight into the Therapeutic Potential of a Bicyclic Hydroxypyridone Compound 2-[(2,4-Dichlorophenyl)methyl]-7-hydroxy-1,2,3,4-tetrahydro-8H-pyrido[1,2-a]pyrazin-8-one as COMT Inhibitor in the Treatment of Parkinson's Disease: A Molecular Dynamic Simulation Approach.
Subair, Temitayo I; Akawa, Oluwole B; Soremekun, Opeyemi S; Olotu, Fisayo A; Soliman, Mahmoud E S.
Affiliation
  • Subair TI; Molecular Bio-computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4001, South Africa.
  • Akawa OB; Molecular Bio-computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4001, South Africa.
  • Soremekun OS; Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Afe Babalola University, Ado, Ekiti State, Nigeria.
  • Olotu FA; Molecular Bio-computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4001, South Africa.
  • Soliman MES; Molecular Bio-computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4001, South Africa.
Chem Biodivers ; 18(9): e2100204, 2021 Sep.
Article in En | MEDLINE | ID: mdl-34252268
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Full text: 1 Database: MEDLINE Main subject: Parkinson Disease / Catechol O-Methyltransferase / Molecular Dynamics Simulation / Catechol O-Methyltransferase Inhibitors / Antiparkinson Agents Limits: Humans Language: En Year: 2021 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Parkinson Disease / Catechol O-Methyltransferase / Molecular Dynamics Simulation / Catechol O-Methyltransferase Inhibitors / Antiparkinson Agents Limits: Humans Language: En Year: 2021 Type: Article