Clinical impact of PET/MRI in oligometastatic colorectal cancer.
Br J Cancer
; 125(7): 975-982, 2021 09.
Article
in En
| MEDLINE
| ID: mdl-34282295
ABSTRACT
BACKGROUND:
Oligometastatic colorectal cancer (CRC) is potentially curable and demands individualised strategies.METHODS:
This single-centre retrospective study investigated if positron emission tomography (PET)/magnetic resonance imaging (MR) had a clinical impact on oligometastatic CRC relative to the standard of care imaging (SCI). Adult patients with oligometastatic CRC on SCI who also underwent PET/MR between 3/2016 and 3/2019 were included. The exclusion criterion was lack of confirmatory standard of reference, either surgical pathology, intraoperative gross confirmation or imaging follow-up. SCI consisted of contrast-enhanced (CE) computed tomography (CT) of the chest/abdomen/pelvis, abdominal/pelvic CE-MR, and/or CE whole-body PET/CT with diagnostic quality (i.e. standard radiation dose) CT. Follow-up was evaluated until 3/2020.RESULTS:
Thirty-one patients constituted the cohort, 16 (52%) male, median patient age was 53 years (interquartile range 49-65 years). PET/MR and SCI results were divergent in 19% (95% CI 9-37%) of the cases, with PET/MR leading to management changes in all of them. The diagnostic accuracy of PET/MR was 90 ± 5%, versus 71 ± 8% for SCI. In a pairwise analysis, PET/MR outperformed SCI when compared to the reference standard (p = 0.0412).CONCLUSIONS:
These findings suggest the potential usefulness of PET/MR in the management of oligometastatic CRC.
Full text:
1
Database:
MEDLINE
Main subject:
Magnetic Resonance Imaging
/
Colorectal Neoplasms
/
Tomography, X-Ray Computed
/
Positron-Emission Tomography
Type of study:
Diagnostic_studies
/
Observational_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Year:
2021
Type:
Article