Cigarette Smoke Specifically Affects Small Airway Epithelial Cell Populations and Triggers the Expansion of Inflammatory and Squamous Differentiation Associated Basal Cells.

Wohnhaas, Christian T; Gindele, Julia A; Kiechle, Tobias; Shen, Yang; Leparc, Germán G; Stierstorfer, Birgit; Stahl, Heiko; Gantner, Florian; Viollet, Coralie; Schymeinsky, Jürgen; Baum, Patrick

Wohnhaas, Christian T; Gindele, Julia A; Kiechle, Tobias; Shen, Yang; Leparc, Germán G; Stierstorfer, Birgit; Stahl, Heiko; Gantner, Florian; Viollet, Coralie; Schymeinsky, Jürgen; Baum, Patrick.

Affiliation

Wohnhaas CT; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Gindele JA; Department of Biology, University of Konstanz, 78457 Konstanz, Germany.
Kiechle T; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Shen Y; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Leparc GG; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Stierstorfer B; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Stahl H; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Gantner F; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Viollet C; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Schymeinsky J; Department of Biology, University of Konstanz, 78457 Konstanz, Germany.
Baum P; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.

Int J Mol Sci ; 22(14)2021 Jul 16.

Article in En | MEDLINE | ID: mdl-34299265

Subject(s)

Airway Remodeling/drug effects; Alveolar Epithelial Cells/drug effects; Cigarette Smoking/adverse effects; Epithelial Cells/metabolism; Alveolar Epithelial Cells/metabolism; Alveolar Epithelial Cells/pathology; Cell Differentiation/drug effects; Cells, Cultured; Cigarette Smoking/metabolism; Epithelial Cells/drug effects; Humans; Neoplasms, Basal Cell/metabolism; Primary Cell Culture; Pulmonary Disease, Chronic Obstructive/etiology; Pulmonary Disease, Chronic Obstructive/metabolism; Pulmonary Disease, Chronic Obstructive/pathology; Respiratory Mucosa/metabolism; Respiratory Mucosa/pathology; Smoke; Smoking/adverse effects; Smoking/metabolism

Key words

ACE2; COPD; basal cells; cigarette smoke; lineage trajectory; single-cell transcriptomics; small airway epithelial cells

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Full text: 1 Database: MEDLINE Main subject: Epithelial Cells / Alveolar Epithelial Cells / Airway Remodeling / Cigarette Smoking Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Year: 2021 Type: Article

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