Magnesium lithospermate B ameliorates hypobaric hypoxia-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition and its potential targets.

Wang, Yafeng; Duo, Delong; Yan, Yingjun; He, Rongyue; Wu, Xinan

Wang, Yafeng; Duo, Delong; Yan, Yingjun; He, Rongyue; Wu, Xinan.

Affiliation

Wang Y; The First Hospital of Lanzhou University, Lanzhou 730000, China; Qinghai Provincial People's Hospitalï¼Xining 810007,China. Electronic address: gyyxgzz@outlook.com.
Duo D; Qinghai Provincial People's Hospitalï¼Xining 810007,China.
Yan Y; Qinghai Provincial People's Hospitalï¼Xining 810007,China.
He R; Qinghai Provincial People's Hospitalï¼Xining 810007,China.
Wu X; The First Hospital of Lanzhou University, Lanzhou 730000, China. Electronic address: xinanwu6511@163.com.

Biomed Pharmacother ; 130: 110560, 2020 Oct.

Article in En | MEDLINE | ID: mdl-34321157

Subject(s)

Drugs, Chinese Herbal/pharmacology; Endothelium, Vascular/drug effects; Endothelium, Vascular/metabolism; Hypertension, Pulmonary/etiology; Hypertension, Pulmonary/metabolism; Hypoxia/complications; Animals; Biomarkers; Disease Management; Disease Models, Animal; Disease Susceptibility; Endothelium, Vascular/pathology; Gene Expression; Hypertension, Pulmonary/diagnosis; Hypertension, Pulmonary/drug therapy; Hypertrophy, Right Ventricular/etiology; Hypertrophy, Right Ventricular/metabolism; Hypertrophy, Right Ventricular/pathology; Rats; Signal Transduction

Key words

Endothelial-to-mesenchymal transition; Hypoxia; Magnesium lithospermate B; Potential targets; Pulmonary arterial hypertension

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Full text: 1 Database: MEDLINE Main subject: Drugs, Chinese Herbal / Endothelium, Vascular / Hypertension, Pulmonary / Hypoxia Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies Limits: Animals Language: En Year: 2020 Type: Article

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