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Assessment of the safety, pharmacokinetics and pharmacodynamics of GSK3335065, an inhibitor of kynurenine monooxygenase, in a randomised placebo-controlled first-in-human study in healthy volunteers.
Fernando, Disala; Dimelow, Richard; Gorey, Ciara; Zhu, Xinyi; Muya, Catherine; Parker, Connie; Wright, Wayne; Soleman, Sara; Walsh, Sarah; Crause, Madelein; Vlasakakis, Georgios; Guiney, William; Robertson, Nicola; Bergeal, Marylise; Cui, Yi; Krug, Alexander W; Uings, Iain.
Affiliation
  • Fernando D; Clinical Unit Cambridge, Addenbrookes Centre for Clinical Investigation, Cambridge, UK.
  • Dimelow R; GlaxoSmithKline Medicines Research Centre, Stevenage, UK.
  • Gorey C; GlaxoSmithKline Medicines Research Centre, Stevenage, UK.
  • Zhu X; GlaxoSmithKline Medicines Research Centre, Stevenage, UK.
  • Muya C; GlaxoSmithKline Medicines Research Centre, Stevenage, UK.
  • Parker C; GlaxoSmithKline David Jack Centre, Ware, UK.
  • Wright W; GlaxoSmithKline David Jack Centre, Ware, UK.
  • Soleman S; Clinical Unit Cambridge, Addenbrookes Centre for Clinical Investigation, Cambridge, UK.
  • Walsh S; Clinical Unit Cambridge, Addenbrookes Centre for Clinical Investigation, Cambridge, UK.
  • Crause M; Clinical Unit Cambridge, Addenbrookes Centre for Clinical Investigation, Cambridge, UK.
  • Vlasakakis G; GlaxoSmithKline Medicines Research Centre, Stevenage, UK.
  • Guiney W; GlaxoSmithKline David Jack Centre, Ware, UK.
  • Robertson N; GlaxoSmithKline David Jack Centre, Ware, UK.
  • Bergeal M; GlaxoSmithKline David Jack Centre, Ware, UK.
  • Cui Y; GlaxoSmithKline Medicines Research Centre, Stevenage, UK.
  • Krug AW; Vertex Pharmaceuticals, Boston, MA, USA.
  • Uings I; GlaxoSmithKline Medicines Research Centre, Stevenage, UK.
Br J Clin Pharmacol ; 88(2): 865-870, 2022 02.
Article in En | MEDLINE | ID: mdl-34327739
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Full text: 1 Database: MEDLINE Main subject: Pancreatitis / Kynurenine Type of study: Clinical_trials Limits: Humans / Male Language: En Year: 2022 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Pancreatitis / Kynurenine Type of study: Clinical_trials Limits: Humans / Male Language: En Year: 2022 Type: Article