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Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation.
Esperante, Sebastián A; Varejao, Nathalia; Pinheiro, Francisca; Sant'Anna, Ricardo; Luque-Ortega, Juan Román; Alfonso, Carlos; Sora, Valentina; Papaleo, Elena; Rivas, Germán; Reverter, David; Ventura, Salvador.
Affiliation
  • Esperante SA; Institut de Biotecnologia i de Biomedicina and Departament de Bioquímica i de Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain. Electronic address: sesperante@infant.org.ar.
  • Varejao N; Institut de Biotecnologia i de Biomedicina and Departament de Bioquímica i de Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain.
  • Pinheiro F; Institut de Biotecnologia i de Biomedicina and Departament de Bioquímica i de Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain.
  • Sant'Anna R; Institut de Biotecnologia i de Biomedicina and Departament de Bioquímica i de Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain.
  • Luque-Ortega JR; Molecular Interactions Facility, Centro de Investigaciones Biológicas Margarita Salas, CSIC, Madrid, Spain.
  • Alfonso C; Systems Biochemistry of Bacterial Division Laboratory, Centro de Investigaciones Biológicas Margarita Salas, CSIC, Madrid, Spain.
  • Sora V; Computational Biology Laboratory, Danish Cancer Society Research Center, Copenhagen, Denmark; Cancer Systems Biology, Health and Technology Department, Section for Bioinformatics, Technical University of Denmark, Lyngby, Denmark.
  • Papaleo E; Computational Biology Laboratory, Danish Cancer Society Research Center, Copenhagen, Denmark; Cancer Systems Biology, Health and Technology Department, Section for Bioinformatics, Technical University of Denmark, Lyngby, Denmark.
  • Rivas G; Systems Biochemistry of Bacterial Division Laboratory, Centro de Investigaciones Biológicas Margarita Salas, CSIC, Madrid, Spain.
  • Reverter D; Institut de Biotecnologia i de Biomedicina and Departament de Bioquímica i de Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain.
  • Ventura S; Institut de Biotecnologia i de Biomedicina and Departament de Bioquímica i de Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain. Electronic address: salvador.ventura@uab.es.
J Biol Chem ; 297(3): 101039, 2021 09.
Article in En | MEDLINE | ID: mdl-34343569
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Full text: 1 Database: MEDLINE Main subject: Prealbumin / Mutation, Missense / Amyloid Neuropathies, Familial Type of study: Risk_factors_studies Limits: Humans Language: En Year: 2021 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Prealbumin / Mutation, Missense / Amyloid Neuropathies, Familial Type of study: Risk_factors_studies Limits: Humans Language: En Year: 2021 Type: Article