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X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor.
Banerjee, Souvik; Mahmud, Foyez; Deng, Shanshan; Ma, Lingling; Yun, Mi-Kyung; Fakayode, Sayo O; Arnst, Kinsie E; Yang, Lei; Chen, Hao; Wu, Zhongzhi; Lukka, Pradeep B; Parmar, Keyur; Meibohm, Bernd; White, Stephen W; Wang, Yuxi; Li, Wei; Miller, Duane D.
Affiliation
  • Banerjee S; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
  • Mahmud F; Department of Physical Sciences, College of STEM, University of Arkansas Fort Smith, Fort Smith, Arkansas 72913, United States.
  • Deng S; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
  • Ma L; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
  • Yun MK; Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Fakayode SO; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.
  • Arnst KE; Department of Physical Sciences, College of STEM, University of Arkansas Fort Smith, Fort Smith, Arkansas 72913, United States.
  • Yang L; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
  • Chen H; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.
  • Wu Z; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
  • Lukka PB; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
  • Parmar K; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
  • Meibohm B; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
  • White SW; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
  • Wang Y; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.
  • Li W; Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Miller DD; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
J Med Chem ; 64(17): 13072-13095, 2021 09 09.
Article in En | MEDLINE | ID: mdl-34406768
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Full text: 1 Database: MEDLINE Main subject: Quinoxalines / Tubulin Modulators / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Year: 2021 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Quinoxalines / Tubulin Modulators / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Year: 2021 Type: Article