Non-toxic polymer nanovectors for improved delivery of dexamethasone.

Ede, Benjamin C; Diamanti, Paraskevi; Williams, David S; Blair, Allison

Ede, Benjamin C; Diamanti, Paraskevi; Williams, David S; Blair, Allison.

Affiliation

Ede BC; School of Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol, BS8 1TD, UK.
Diamanti P; School of Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol, BS8 1TD, UK.
Williams DS; Bristol Institute for Transfusion Sciences, NHS Blood and Transplant Filton, Bristol, UK.
Blair A; School of Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol, BS8 1TD, UK.

Sci Rep ; 11(1): 17263, 2021 08 26.

Article in En | MEDLINE | ID: mdl-34446801

Subject(s)

Dexamethasone/administration & dosage; Drug Delivery Systems/methods; Nanostructures/chemistry; Polymers/chemistry; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy; Xenograft Model Antitumor Assays/methods; Animals; Antineoplastic Agents, Hormonal/administration & dosage; Antineoplastic Agents, Hormonal/chemistry; Antineoplastic Agents, Hormonal/pharmacokinetics; Child; Dexamethasone/chemistry; Dexamethasone/pharmacokinetics; Drug Liberation; Humans; Kaplan-Meier Estimate; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/metabolism; Treatment Outcome; Tumor Cells, Cultured; Young Adult

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Full text: 1 Database: MEDLINE Main subject: Polymers / Dexamethasone / Drug Delivery Systems / Xenograft Model Antitumor Assays / Nanostructures / Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Limits: Adult / Animals / Child / Humans Language: En Year: 2021 Type: Article

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