Aim32 is a dual-localized 2Fe-2S mitochondrial protein that functions in redox quality control.

Zhang, Danyun; Dailey, Owen R; Simon, Daniel J; Roca-Datzer, Kamilah; Jami-Alahmadi, Yasaman; Hennen, Mikayla S; Wohlschlegel, James A; Koehler, Carla M; Dabir, Deepa V.

Affiliation

Zhang D; Department of Chemistry and Biochemistry, UCLA, Los Angeles, California, USA.
Dailey OR; Department of Biology, Loyola Marymount University, Los Angeles, California, USA.
Simon DJ; Department of Biology, Loyola Marymount University, Los Angeles, California, USA.
Roca-Datzer K; Department of Biology, Loyola Marymount University, Los Angeles, California, USA.
Jami-Alahmadi Y; Department of Biological Chemistry, UCLA, Los Angeles, California, USA.
Hennen MS; Department of Biology, Loyola Marymount University, Los Angeles, California, USA.
Wohlschlegel JA; Department of Biological Chemistry, UCLA, Los Angeles, California, USA.
Koehler CM; Department of Chemistry and Biochemistry, UCLA, Los Angeles, California, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, USA.
Dabir DV; Department of Biology, Loyola Marymount University, Los Angeles, California, USA. Electronic address: ddabir@lmu.edu.

J Biol Chem ; 297(4): 101135, 2021 10.

Article in En | MEDLINE | ID: mdl-34461091

Subject(s)

Ferredoxins/metabolism; Saccharomyces cerevisiae/metabolism; Electron Transport Complex IV/genetics; Electron Transport Complex IV/metabolism; Ferredoxins/genetics; Membrane Transport Proteins/genetics; Membrane Transport Proteins/metabolism; Mitochondrial Membrane Transport Proteins/genetics; Mitochondrial Membrane Transport Proteins/metabolism; Mitochondrial Precursor Protein Import Complex Proteins; Mitochondrial Proteins/genetics; Mitochondrial Proteins/metabolism; Mutation; Nuclear Proteins/genetics; Nuclear Proteins/metabolism; Oxidation-Reduction; Oxidoreductases Acting on Sulfur Group Donors/genetics; Oxidoreductases Acting on Sulfur Group Donors/metabolism; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae Proteins/metabolism

Key words

disulfide; mitochondria; mitochondrial transport; protein import; redox regulation; thiol; thioredoxin