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Ginsenoside 20(S)-Rh2 promotes cellular pharmacokinetics and intracellular antibacterial activity of levofloxacin against Staphylococcus aureus through drug efflux inhibition and subcellular stabilization.
Chen, Xiao-Yang; Qian, Fei; Wang, Yao-Yao; Liu, Yan; Sun, Yuan; Zha, Wei-Bin; Hao, Kun; Zhou, Fang; Wang, Guang-Ji; Zhang, Jing-Wei.
Affiliation
  • Chen XY; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China.
  • Qian F; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210023, China.
  • Wang YY; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China.
  • Liu Y; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China.
  • Sun Y; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China.
  • Zha WB; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China.
  • Hao K; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China.
  • Zhou F; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China.
  • Wang GJ; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China. guangjiwang@hotmail.com.
  • Zhang JW; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China. zhangjw_cnnj@sina.com.
Acta Pharmacol Sin ; 42(11): 1930-1941, 2021 11.
Article in En | MEDLINE | ID: mdl-34462563
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Full text: 1 Database: MEDLINE Main subject: Staphylococcus aureus / Subcellular Fractions / Ginsenosides / Levofloxacin / Intracellular Fluid / Anti-Bacterial Agents Limits: Animals / Female / Humans / Male Language: En Year: 2021 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Staphylococcus aureus / Subcellular Fractions / Ginsenosides / Levofloxacin / Intracellular Fluid / Anti-Bacterial Agents Limits: Animals / Female / Humans / Male Language: En Year: 2021 Type: Article