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Identification of N,N-arylalkyl-picolinamide derivatives targeting the RNA-binding protein HuR, by combining biophysical fragment-screening and molecular hybridization.
Della Volpe, S; Linciano, P; Listro, R; Tumminelli, E; Amadio, M; Bonomo, I; Elgaher, W A M; Adam, S; Hirsch, A K H; Boeckler, F M; Vasile, F; Rossi, D; Collina, S.
Affiliation
  • Della Volpe S; Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100, Pavia, Italy; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Campus building E8.1, 66123 Saarbrücken, Germany; Department of Pharmacy, Saarland University, C
  • Linciano P; Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100, Pavia, Italy. Electronic address: pasquale.linciano@unipv.it.
  • Listro R; Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100, Pavia, Italy. Electronic address: roberta.listro01@universitadipavia.it.
  • Tumminelli E; Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100, Pavia, Italy; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Campus building E8.1, 66123 Saarbrücken, Germany. Electronic address: elisabetta.tumminelli01@un
  • Amadio M; Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100, Pavia, Italy. Electronic address: marialaura.amadio@unipv.it.
  • Bonomo I; Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy. Electronic address: isabelle.bonomo@unitn.it.
  • Elgaher WAM; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Campus building E8.1, 66123 Saarbrücken, Germany. Electronic address: Walid.Mohammad@helmholtz-hips.de.
  • Adam S; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Campus building E8.1, 66123 Saarbrücken, Germany. Electronic address: Sebastian.Adam@helmholtz-hips.de.
  • Hirsch AKH; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Campus building E8.1, 66123 Saarbrücken, Germany; Department of Pharmacy, Saarland University, Campus Building E8.1, 66123 Saarbrücken, Germany. Electronic address: Anna.Hirsch@helmholtz-
  • Boeckler FM; Department of Pharmacy and Biochemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen, Germany; Center for Bioinformatics Tübingen (ZBIT), Eberhard Karls Universität Tübingen, Tübingen, Germany. Electronic address: frank.boeckler@uni-tuebingen.de.
  • Vasile F; Department of Chemistry, University of Milan, Via Golgi 19, 20133 Milano, Italy. Electronic address: francesca.vasile@unimi.it.
  • Rossi D; Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100, Pavia, Italy. Electronic address: daniela.rossi@unipv.it.
  • Collina S; Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100, Pavia, Italy. Electronic address: simona.collina@unipv.it.
Bioorg Chem ; 116: 105305, 2021 11.
Article in En | MEDLINE | ID: mdl-34482166
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Full text: 1 Database: MEDLINE Main subject: Picolinic Acids / RNA-Binding Proteins Type of study: Diagnostic_studies / Screening_studies Limits: Humans Language: En Year: 2021 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Picolinic Acids / RNA-Binding Proteins Type of study: Diagnostic_studies / Screening_studies Limits: Humans Language: En Year: 2021 Type: Article